If you are using Magento 2 and you got this 500 error from admin login page. Your Content Security Policy header are too long. Use Nginx or reduce your headers.

Problem is AP_IOBUFSIZE cannot be changed by a conf file it is hardcoded in to the sourcecode. You have only 8192 Bytes and this is offen to low. If you reach this limit your apache will crash and restart.

AP_IOBUFSIZE 8192

Look at the Bugzilla from Apache Webserver

https://bz.apache.org/bugzilla/show_bug.cgi?id=64919